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Coronary Heart Disease Risk Assessment by Traditional Risk Factors and Newer Subclinical Disease ImagingIs a "One-Size-Fits-All" Approach the Best Option?
Sarah Rosner Preis, ScD, MPH;
Christopher J. O’Donnell, MD, MPH
Arch Intern Med. 2007;167(22):2399-2401.
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Coronary heart disease (CHD) and other atherosclerotic cardiovascular diseases (CVDs) remain the leading cause of death and disability in women as well as men in the Western and developing world.1 Clinical CHD, manifested as angina or an acute coronary syndrome, results from thrombosis in an unstable atherosclerotic plaque in the coronary arteries.2 Clinicians and researchers alike are keenly interested in the identification of optimal methods for prediction of CHD risk. Thus, it is not surprising that there is great interest in direct imaging of the heart for the presence and extent of coronary artery atherosclerosis detected by cardiac computed tomography (CT). Multiple studies of tens of thousands of patients referred for cardiac CT measurement of coronary artery calcium (CAC) provide consistent evidence that the presence and extent of CAC predicts strongly increased risks for CHD.3 However, much of the evidence . . . [Full Text of this Article]
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