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The TrapProfessional Exposure to Human Immunodeficiency Virus Antibody–Negative Blood With High Viral Load
Stefano Giulieri, MD;
Veronique Schiffer, MD;
Sabine Yerly, PhD;
Philippe Burgisser, MD;
Bernard Hirschel, MD;
Matthias Cavassini, MD
Arch Intern Med. 2007;167(22):2524-2526.
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INTRODUCTION
The Centers for Disease Control and Prevention, national public health agencies, and an expert committee of the European Commission have recently published updated guidelines on postexposure prophylaxis (PEP) of occupational human immunodeficiency virus (HIV) exposure.1-2 Management of occupational HIV exposure relies heavily on HIV antibody testing of the source patient. However, patients with acute HIV infection may be antibody negative yet particularly contagious because of high viremia. We report 2 cases involving health care workers who were exposed to patients with acute primary HIV infection (PHI). The patients were in the "window period" of seroconversion, during which detection of HIV p24 antigen provided the definitive indication for PEP. We also review the literature on the topic.
REPORT OF CASES
CASE 1
A hospital laboratory technician sustained a deep hand injury while handling a blood sample from a . . . [Full Text of this Article] CASE 2
COMMENT
AUTHOR INFORMATION
Author Affiliations: Service of Infectious Diseases (Drs Giulieri and Cavassini) and Laboratory of Immunology and Allergy (Dr Burgisser), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland; and Division of Infectious Diseases (Drs Schiffer and Hirschel) and Laboratory of Virology, Division of Infectious Diseases (Dr Yerly), University Hospital of Geneva, Geneva, Switzerland.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Occupational HIV Exposure During Primary Infection
JWatch Infect. Diseases 2007;2007:2-2.
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