 |
|
COMMENTS & OPINIONS
Erythropoietin Levels and Androgens Use: What Is Their Relationship in the Correction of Anemia?
Charles J. Diskin, MD
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
While Daniell1 writes that androgen therapy is a proven treatment of anemia in patients with end-stage renal disease (ESRD) through the stimulation of endogenous erythropoietin levels or some other erythropoietic cells, Spivak2 notes in his reply that such an assertion contradicts the known physiology of erythropoiesis. Perhaps I can help resolve some of the conflict. Thirty years ago when we used androgens in the treatment of ESRD, we had just begun to realize that the kidney participated in erythrocyte regulation. At that time, we used a mouse bioassay for detecting the functional presence of erythropoietin, but it could not distinguish between the absence of erythropoietin and the lack of its efficacy due to inhibiters. We then developed an enzyme-linked immunosorbent assay to detect the actual quantities of erythropoietin in patients with ESRD and found that they had higher erythropoietin levels than our control patients and that . . . [Full Text of this Article]
AUTHOR INFORMATION
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
RELATED LETTERS
Erythropoietin Resistance During Androgen Deficiency
Harry W. Daniell
Arch Intern Med. 2006;166(17):1923.
EXTRACT
| FULL TEXT
Erythropoietin Resistance During Androgen Deficiency—Reply
Jerry L. Spivak
Arch Intern Med. 2006;166(17):1923-1924.
EXTRACT
| FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Erythropoietin, haemoglobin, heart failure, and mortality
Diskin
Eur Heart J 2008;29:2695-2695.
FULL TEXT
|
