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What We Know and What We Don't Know

Mary Charlson, MD; Marcus McFerren, PhD, MD

Arch Intern Med. 2007;167(4):325-326.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Garlic (Allium sativum) and wild garlic (Allium ursinum) have been used since antiquity for the treatment of cardiovascular and infectious diseases. The first written record of garlic use in cardiovascular health appeared 3500 years ago in the Codex Ebers of ancient Egypt.¹ Western investigation of garlic and its medicinal properties began about 200 years ago.^2-3 While garlic has been evaluated for its anti-infective, antioxidant, and anticancer properties, a large number of recent basic and clinical studies have focused on its potential effect in preventing cardiovascular disease.

In this issue of the ARCHIVES, Gardner et al⁴ evaluated the efficacy of raw garlic, powdered garlic, and aged garlic vs placebo in lowering low-density lipoprotein cholesterol (LDL-C) during 6 months in patients with moderately elevated LDL-C concentrations. All participants received tablets and sandwiches, and there were placebo tablets and placebo . . . [Full Text of this Article]

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Effect of Raw Garlic vs Commercial Garlic Supplements on Plasma Lipid Concentrations in Adults With Moderate Hypercholesterolemia: A Randomized Clinical Trial
Christopher D. Gardner, Larry D. Lawson, Eric Block, Lorraine M. Chatterjee, Alexandre Kiazand, Raymond R. Balise, and Helena C. Kraemer
Arch Intern Med. 2007;167(4):346-353.
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