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Context and Overview

Clyde B. Schechter, MA, MD

Arch Intern Med. 2007;167(5):428-429.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In this issue, Terry et al¹ report on the findings of a comparison of cardiovascular disease (CVD) risk factors among Framingham Heart Study offspring participants with and without parents who survived to 85 years or older. They also found that the incidence and progression of these risk factors during 12 years of follow-up is reduced among these offspring. The prevalence findings mirror in a community-based study what others² have found in more selected groups: the children of parents who live exceptionally long lives have a reduced prevalence of CVD risk factors starting as soon as early mid-life.

It is well to place this study in the broader context of research into the determinants of exceptional longevity and the associated research agenda. Whereas overall lifespan exhibits only a low degree of heritability, survival to a very advanced age shows high heritability. Indeed, the heritability increases with . . . [Full Text of this Article]

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Characteristics of Framingham Offspring Participants With Long-lived Parents
Dellara F. Terry, Jane C. Evans, Michael J. Pencina, Joanne M. Murabito, Ramachandran S. Vasan, Philip A. Wolf, Margaret Kelly-Hayes, Daniel Levy, Ralph B. D’Agostino, Sr, and Emelia J. Benjamin
Arch Intern Med. 2007;167(5):438-444.
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