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Jutta Martha Halbekath; Stefanie Schenk; Andreas von Maxen, MD; Gabriele Meyer, PhD; Ingrid Mühlhauser, MD

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With concern, we read the trials conducted by Sato and colleagues comparing risedronate sodium with placebo in male patients with stroke¹ and female patients with Alzheimer disease (AD).²

Both trials were conducted in a single center. Yet, patients (500 women with AD and 280 men with stroke) were recruited in only 3 months: the patients with AD in March and April 2003 and the patients with stroke in April and May 2003. Related to a third single-center trial with risedronate in 374 female patients with stroke at the same hospital that was published by the group in 2005,³ a correspondence letter⁴ expressed concern about the high frequency of recruitment, which was performed in only 4 months (between April and July 2003).³ In their reply, Sato and colleagues⁵ stated that their hospital is a specialized center . . . [Full Text of this Article]

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RELATED LETTER

Risedronate for the Prevention of Hip Fractures: Concern About Validity of Trials—Reply
Yoshihiro Sato
Arch Intern Med. 2007;167(5):514-515.
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