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Can Aspirin Keep Mortality at Bay?
John A. Baron, MD
Arch Intern Med. 2007;167(6):535-536.
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In this issue of the ARCHIVES, Chan et al1 report a strong association between aspirin use and reduced cardiovascular mortality in middle-aged and older women. This analysis of almost 80 000 women is derived from the Nurses' Health Study (NHS), a well-known and well-conducted observational research effort that has been ongoing for about 30 years. Readers may recall another study on a similar topic published in 2005, the Women's Health Study (WHS).2 That trial, carried out during more than 11 years in almost 40 000 women, reported that aspirin therapy had no effect on cardiovascular or other mortality. Which of these mega-studies is right? Both somehow? Neither?
PREVIOUS STUDIES OF ASPIRIN USE AND CARDIOVASCULAR MORTALITY
The NHS and the WHS have emerged in the context of a great deal of previous research that provides important background about the effects of aspirin therapy on cardiovascular end points. In patients with clinical atherosclerotic disease, antiplatelet treatment, . . . [Full Text of this Article]
NURSES’ HEALTH STUDY VS WOMEN'S HEALTH STUDY
AUTHOR INFORMATION
RELATED LETTER
A Possible Overestimation of the Effect of Aspirin
Jaapjan D. Snoep, Olaf M. Dekkers, and Jan P. Vandenbroucke
Arch Intern Med. 2007;167(21):2372-2373.
EXTRACT
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RELATED ARTICLE
Long-term Aspirin Use and Mortality in Women
Andrew T. Chan, JoAnn E. Manson, Diane Feskanich, Meir J. Stampfer, Graham A. Colditz, and Charles S. Fuchs
Arch Intern Med. 2007;167(6):562-572.
ABSTRACT
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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A Possible Overestimation of the Effect of Aspirin
Snoep et al.
Arch Intern Med 2007;167:2372-2373.
FULL TEXT
Does Aspirin Lower Mortality in Women?
JWatch General 2007;2007:2-2.
FULL TEXT
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