This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Nutrition/ Malnutrition  • Adverse Effects  • Alert me on articles by topic  Social Bookmarking   What's this?

George I. Varughese, MRCPI, MRCP(UK); Abd A. Tahrani, MD, MRCP; John H. B. Scarpello, MD, FRCP

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We applaud Ting et al¹ for their study demonstrating the risk of vitamin B₁₂ deficiency with increasing dose and duration of metformin use. In contrast to previous reports, their study demonstrated no excess risk of vitamin B₁₂ deficiency among metformin users who currently use histamine₂-receptor blockers or proton pump inhibitors.¹ This statement should be interpreted very cautiously, although the authors allude to the fact that the lack of association in their study may stem from imprecise hospital-based medication records and inability to track the use of histamine₂-receptor blockers or proton pump inhibitors. Gastrointestinal symptoms can be a limiting factor in optimizing metformin therapy, and metformin has been recognized not to alter intestinal motility or bacterial overgrowth.^1-2 Interestingly, almost one half of adult consumers of over-the-counter histamine₂-receptor blockers have been reportedly using . . . [Full Text of this Article]

AUTHOR INFORMATION


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?