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Jaewon Oh, MD; Ji Hyung Chung, PhD; Yangsoo Jang, MD, PhD

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The meta-analysis of the exogenous insulin use and hypertension in type 2 diabetes mellitus by Tseng¹ showed that insulin users were at higher risk for development of hypertension compared with nonusers, suggesting there might be an unknown relationship between exogenous insulin use and hypertension. Hyperinsulinemia, along with insulin resistance, is a well-known risk factor for hypertension, but whether insulin itself could have the potential for the development of hypertension independent of insulin resistance is controversial. Therefore, the underlying mechanisms of insulin-induced hypertension remain to be studied further, although there are some explanations suggested by Tseng¹ such as induction of oxidative stress and increased plasma catecholamine levels.

A recent basic research study might provide a novel explanation for this phenomenon. Visfatin, an adipokine, has been reported to lower plasma glucose levels through binding and activating the insulin receptor.² Haider et . . . [Full Text of this Article]

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