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Phosphorus Comes of Age as a Cardiovascular Risk Factor
Robert N. Foley, MD
Arch Intern Med. 2007;167(9):873-874.
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Phosphorus is an important biochemical entity.1 For example, Biochemistry 101 tells us that adenosine triphosphate is the molecular currency of intracellular energy transfer; cyclic adenosine monophosphate and cyclic guanosine monophosphate are second messengers regulating many biochemical processes; addition and removal of phosphorus moieties change the catalytic activity of many enzymes; the backbones of DNA and RNA are composed of phosphorus bound to sugars; 2,3-diphosphoglycerate is a critical regulator of oxygen dissociation from hemoglobin; phosphorus is a component of important coenzymes, like nicotinamide adenine dinucleotide; and phosphorus is an integral component of structural molecules like phosphoproteins and phospholipids.
It would seem, therefore, that regulation of bodily phosphorus content should be an important homeostatic need, and the relatively narrow range of physiological serum phosphorus concentrations supports this contention. Phosphorus is ubiquitous in typical Western diets. In the short term, serum phosphorus concentrations are determined by dietary intake, gastrointestinal . . . [Full Text of this Article]
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Relations of Serum Phosphorus and Calcium Levels to the Incidence of Cardiovascular Disease in the Community
Ravi Dhingra, Lisa M. Sullivan, Caroline S. Fox, Thomas J. Wang, Ralph B. D’Agostino, Sr, J. Michael Gaziano, and Ramachandran S. Vasan
Arch Intern Med. 2007;167(9):879-885.
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