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Kenneth J. Mukamal, MD, MPH, MA; Stephanie E. Chiuve, ScD; Eric B. Rimm, ScD

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In reply

We thank Fink for his personal and professional interest in our work.¹ As our analyses were primarily directed at the biological and clinical question of whether alcohol use is related to the occurrence of coronary heart disease, we chose incident coronary disease as our primary outcome. Our article did not, as Fink suggests, provide information on cause-specific mortality, which is a function of both incidence of disease and its case-fatality rate.

With that said, Fink is clearly correct that the relation of alcohol use with total mortality is of obvious import as well and indeed has been addressed at length in a recent meta-analysis published in the Archives.² We examined the relationship of alcohol use with total mortality in this group of men with healthy lifestyle behaviors, with no censoring for incident nonfatal . . . [Full Text of this Article]

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