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Yair Liel, MD

	Since this article does not have an abstract, we have provided the first 123 words of the full text and any section headings.

Åsvold et al¹ have recently reported on lower thyrotropin levels in smokers vs nonsmokers and increasing thyrotropin levels with time following smoking cessation. The data are interesting and may further support the recommendation for patients with Graves disease to stop smoking. However, previous studies have pointed out a direct correlation between thyrotropin level and body mass,^2-3 and in addition there is a well-recognized weight-gaining influence of smoking cessation.^4-5 Therefore, I wonder if the observed effect of smoking on thyrotropin level could have, at least partially, been attributed to differences in body mass between smokers and nonsmokers and by weight gain following smoking cessation.

AUTHOR INFORMATION
Correspondence: Dr Liel, Endocrine Unit, Soroka University Medical Center, POB 151, Beer-Sheva 84101, Israel (liel@bgu.ac.il).

1. Åsvold BO, Bjøro T, Nilsen TIL, Vatten LJ. Tobacco smoking and thyroid function. Arch Intern Med. 2007;167(13):1428-1432. FREE FULL TEXT 2. Iacobellis G, Ribaudo MC, Zappaterreno A, Iannucci CV, Leonetti F. Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. Clin Endocrinol (Oxf). 2005;62(4):487-491. FULL TEXT | PUBMED 3. Kok P, Roelfsema F, Langendonk JG; et al. High circulating thyrotropin levels in obese women are reduced after body weight loss induced by caloric restriction. J Clin Endocrinol Metab. 2005;90(8):4659-4663. FREE FULL TEXT 4. Hudmon KS, Gritz ER, Clayton S, Nisenbaum R. Eating orientation, postcessation weight gain, and continued abstinence among female smokers receiving an unsolicited smoking cessation intervention. Health Psychol. 1999;18(1):29-36. FULL TEXT | ISI | PUBMED 5. Williamson DF, Madans J, Anda RF, Kleinman JC, Giovino GA, Byers T. Smoking cessation and severity of weight gain in a national cohort. N Engl J Med. 1991;324(11):739-745. ABSTRACT

Arch Intern Med. 2008;168(1):114.

RELATED LETTER

Tobacco Smoking and Thyroid Function: Is Weight Gain a Confounder?—Reply
Bjørn Olav Åsvold, Trine Bjøro, Tom Ivar Nilsen, and Lars J. Vatten
Arch Intern Med. 2008;168(1):114.
EXTRACT | FULL TEXT  

RELATED ARTICLE

Tobacco Smoking and Thyroid Function: A Population-Based Study
Bjørn O. Åsvold, Trine Bjøro, Tom I. L. Nilsen, and Lars J. Vatten
Arch Intern Med. 2007;167(13):1428-1432.
ABSTRACT | FULL TEXT