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COMMENTS & OPINIONS
Acid Suppression Not the Only Culprit of Community-Acquired Pneumonia
David Kerman, MD;
Jamie S. Barkin, MD
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We read with great interest the article finding an increased risk of community-acquired pneumonia (CAP) with the use of proton pump inhibitors.1 While an association was found in a significant number of patients, a direct causal relationship should be entertained with caution. Other factors such as gastroesophageal reflux disease (GERD) must be investigated before holding medication as a potential culprit. Pooled data analysis has shown a direct relationship with GERD and pulmonary disease, specifically GERD and asthma.2 It has also been shown that asthma, smoking, and elevated body mass index are risk factors for CAP.3 Age, unemployment, single marital status, and chronic obstructive pulmonary disease have also been shown to be independent risk factors.4-5 All of these are also risk factors for GERD and must be considered as confounding factors in the development of CAP. It is important to recognize that there is . . . [Full Text of this Article]
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RELATED ARTICLE
Use of Proton Pump Inhibitors and the Risk of Community-Acquired Pneumonia: A Population-Based Case-Control Study
Sinem Ezgi Gulmez, Anette Holm, Henrik Frederiksen, Thøger Gorm Jensen, Court Pedersen, and Jesper Hallas
Arch Intern Med. 2007;167(9):950-955.
ABSTRACT
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RELATED LETTER
Acid Suppression Not the Only Culprit of Community-Acquired Pneumonia—Reply
Sinem Ezgi Gulmez, Jesper Hallas, and Henrik Frederiksen
Arch Intern Med. 2008;168(10):1119.
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