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  Vol. 168 No. 10, May 26, 2008 TABLE OF CONTENTS
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 •Bacterial Infections
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COMMENTS & OPINIONS
Acid Suppression Not the Only Culprit of Community-Acquired Pneumonia

David Kerman, MD; Jamie S. Barkin, MD

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We read with great interest the article finding an increased risk of community-acquired pneumonia (CAP) with the use of proton pump inhibitors.1 While an association was found in a significant number of patients, a direct causal relationship should be entertained with caution. Other factors such as gastroesophageal reflux disease (GERD) must be investigated before holding medication as a potential culprit. Pooled data analysis has shown a direct relationship with GERD and pulmonary disease, specifically GERD and asthma.2 It has also been shown that asthma, smoking, and elevated body mass index are risk factors for CAP.3 Age, unemployment, single marital status, and chronic obstructive pulmonary disease have also been shown to be independent risk factors.4-5 All of these are also risk factors for GERD and must be considered as confounding factors in the development of CAP. It is important to recognize that there is . . . [Full Text of this Article]


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