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COMMENTS AND OPINIONS
The Hurdles of Translating a Single-Center Observation Into Practice—Reply
Pamela N. Peterson, MD, MSPH;
Frederick A. Masoudi, MD, MSPH
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In reply
We appreciate Testa and colleagues' comments regarding our article. As they point out, an underlying assumption of Cox survival models is the proportionality of hazards for the covariates.1 As stated in our article, we assessed the validity of this assumption for each of the covariates, including indication for testing, and found the assumption to be appropriate.2
With respect to the question about the adjustment for diabetes or medical therapy, these variables, in addition to all those in Table 1 of our article,2 were candidates for each of the models. As stated in the article, variable reduction for the final model was performed, removing those variables without a significant relationship with the outcome or that did not exert a meaningful confounding effect on the relationship between exercise tolerance and the outcome.2 Thus, the variables from Table 1 not included . . . [Full Text of this Article]
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