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COMMENTS AND OPINIONS
Fluoroquinolone Use With No Increase in Culture-Negative Tuberculosis
Minoru Matsushima, MD;
Shungo Yamamoto, MD;
Kentaro Iwata, MD, MSc;
David G. Gremillion, MD
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Gaba and coworkers1 addressed the issue of fluoroquinolone use in patients with potential tuberculosis (TB) and concluded that fluoroquinolone exposure was not associated with an increased risk of culture-negative TB. However, we suggest that they failed to address the proper population for the analysis and thus may have reached the wrong conclusion. First, they defined fluoroquinolone use as prescriptions filled in the 12 months before a TB diagnosis was made. The median period between receipt of fluoroquinolone and TB diagnosis was 80 days (interquartile range, 27-250 days). We believe that a short course of a fluoroquinolone, as much as 1 year before tuberculosis diagnosis, could not alter positive culture results. Symptomatic TB mistaken as community-acquired pneumonia is a more likely scenario for recent exposure to fluoroquinolones and the delay in making the TB diagnosis. The analysis . . . [Full Text of this Article]
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