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Sarah N. Hilmer, MBBS, PhD; Darrell R. Abernethy, MD, PhD

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

A strong observational database is emerging to measure adverse drug effects in older adults. The study by Rudolph and colleagues¹ is one of several describing the cumulative risks of adverse effects and of impairments in function, which are associated with exposure to anticholinergic and sedative medications. Rudolph et al¹ used expert consensus to grade medications for their likelihood to cause adverse anticholinergic effects. Their score was associated with the risk of self-reported anticholinergic adverse effects in older patients. The weighting attributed to anticholinergic medications for the Anticholinergic Risk Scale¹ is based on data that were not obtained from frail older people. This may partially explain why the score is more strongly associated with adverse effects in the primary care patients than in the geriatric evaluation and management patients. Increasing impairment in function with exposure to a higher number of anticholinergic . . . [Full Text of this Article]

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