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COMMENTS AND OPINIONS
Measures of Drug Toxicity in Older Adults—Reply
James L. Rudolph, MD, SM;
Marci J. Salow, PharmD;
Michael C. Angelini, PharmD;
Regina E. McGlinchey, PhD
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In reply
We thank Hilmer and Abernathy for their comments and appreciate the opportunity to respond. The older population is at an increased risk for adverse effects of medications. This risk is not limited to anticholinergic medications and includes other drugs such as benzodiazepines, opioids, antidepressants, and antihypertensives.1 There is an urgent need for increased study of the individual, class, and combined adverse events of medications in older patients. The focus of the Anticholinergic Risk Scale (ARS) on anticholinergic medications and the associated adverse events was crucial to our study because it presents a clear clinical message—anticholinergic medications in older patients are associated with toxic effects.
We proposed 2 clinical applications for the ARS: (1) an educational aid to improve clinician understanding of anticholinergic medication toxicity and (2) a screening tool to identify . . . [Full Text of this Article]
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RELATED ARTICLE
The Anticholinergic Risk Scale and Anticholinergic Adverse Effects in Older Persons
James L. Rudolph, Marci J. Salow, Michael C. Angelini, and Regina E. McGlinchey
Arch Intern Med. 2008;168(5):508-513.
ABSTRACT
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RELATED LETTER
Measures of Drug Toxicity in Older Adults
Sarah N. Hilmer and Darrell R. Abernethy
Arch Intern Med. 2008;168(17):1930-1931.
EXTRACT
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