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Pierre Delanaye, MD; Jean-Marie Krzesinski, MD, PhD; Etienne Cavalier, MD

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We read with great interest the article by Kovesdy et al¹ about the association between activated vitamin D (calcitriol) treatment and mortality in chronic kidney disease (CKD). The results are certainly of interest, but as the study is purely observational, these data must be confirmed on prospective randomized studies. At the end of the article, the authors are calling for such randomized studies comparing activated vitamin D and analogues. We have another proposal and working hypothesis that would involve a study comparing active vitamin D (1,25-dihydroxyvitamin D₃ [1,25{OH}2-D3]) with native vitamin D (25-hydroxyvitamin D [25{OH}D]). Indeed, 25(OH)D can bind and directly activate vitamin D receptor. Even if 25(OH)D is 200 to 400 times less active than activated vitamin D, many studies suggest important physiological roles for native vitamin D, even in patient’s receiving hemodialysis.² On one hand, circulating 25(OH)D plasma . . . [Full Text of this Article]

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Association of Activated Vitamin D Treatment and Mortality in Chronic Kidney Disease
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