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COMMENTS AND OPINIONS
Vitamin D Therapy and Reduced Mortality in Chronic Kidney Disease—Reply
Csaba Kovesdy, MD, FASN, CPI;
Shahram Ahmadzadeh, MD;
John Anderson, MD;
Kamyar Kalantar-Zadeh, MD, MPH, PhD
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In reply
Kumar et al point out that the benefit of calcitriol therapy seen in our study may have been related to PTH level lowering, based on the observation that treated patients in our study had higher initial serum PTH concentrations, which declined subsequently.1 This discrepancy in PTH levels among the 2 groups is probably due to the observational nature of our study and the fact that the indication for calcitriol therapy in our cohort was treatment of secondary hyperparathyroidism. This may lead to confounding by medical indication, making it apparently difficult to assess the impact of calcitriol on those with normal PTH levels, as Kumar et al suggested. Our subgroup analyses, however, showed that the benefit of calcitriol was equally present in patient groups with lower (<103 pg/mL) and higher ( 103 pg/mL) . . . [Full Text of this Article]
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