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Hari Kumar K. V. S., MD; Abhyuday Verma, MD; Jayaraman Muthukrishnan, MD; Kirtikumar D. Modi, MD, DM

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The study by Fox et al¹ showed that a change in serum thyrotropin (TSH) concentration within the reference range is associated with changes in body weight. However, the authors' focused only on the weight gain seen with the rise in TSH value, but no data were shown regarding the weight loss associated with the fall in TSH value. These data would have helped in further defining the relation between body weight changes in the normal reference range of TSH value.

The authors considered the normal TSH reference range as between 0.5 mIU/L and 5.0 mIU/L in their study population derived from a community sample. However, there are no data regarding the thyroid antibody status of the participants in their study. The debate about the reference range of TSH in a population is increasing, . . . [Full Text of this Article]

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RELATED LETTER

Obesity and Hypothyroidism: Symbiotic Coexistence—Reply
Caroline S. Fox, Michael J. Pencina, and Ramachandran S. Vasan
Arch Intern Med. 2008;168(19):2168.
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