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Caroline S. Fox, MD, MPH; Michael J. Pencina, PhD; Ramachandran S. Vasan, MD

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Kumar et al note that we only focused on weight gain in the setting of TSH concentration change. In fact, we modeled change in TSH concentration throughout the spectrum (encompassing increases and decrease in values) in relation to weight change (including weight gain and loss). As described in the article, the mean change in TSH concentration was 0.06 mIU/L in women and 0.13 mIU/L in men. The lowest quartile of TSH concentration change includes individuals whose TSH value declined over time (range of TSH values in the lowest quartile, –2.45 to –0.34 mIU/L in women and –3.02 to –0.29 mIU/L in men).¹ Women in the lowest quartile of TSH concentration change gained a mean of 0.5 kg, whereas, overall, mean weight change was 1.5 kg in women. Similarly, men in the lowest quartile of TSH . . . [Full Text of this Article]

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