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Christopher B. Granger, MD; E. Magnus Ohman, MD; Richard C. Becker, MD

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Williamson and colleagues provide an interesting additional context for our findings, including the recent reports of noncardiac intensive care unit patients having a high incidence of thrombocytopenia that is associated with poor outcome. Differences between these reports and our study¹ include the following: (1) our patients were generally not intensive care unit patients, (2) our patients had all received heparin therapy for at least 4 days, (3) our patients included cardiac patients, and (4) our sample size was larger than all these other studies combined.

We considered the use of APACHE II for risk adjustment but elected not to use it because APACHE II and Trauma scores are relevant to critically ill intensive care unit patients. We developed our own score that included markers of disease severity with this specific population, and we found that platelet . . . [Full Text of this Article]

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RELATED LETTER

Risk Factors for Thrombocytopenia in Patients Treated With Prolonged Heparin Therapy
David R. Williamson and Danielle Pilon
Arch Intern Med. 2008;168(19):2170-2171.
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