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Lung Cancer Risk Following Detection of Pulmonary Scarring by Chest Radiography in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial—Invited Commentary
Sigmund A. Weitzman, MD
Arch Intern Med. 2008;168(21):2332.
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An association between cancer and chronic inflammation has been recognized for centuries. Hermann Boerhaave of Leiden (1668-1738) wrote that inflammation might lead to "scirrhus" (scar formation), and that scirrhus "may change to cancer under unfavorable circumstances."1 Many of the cancers related to inflammation are associated with specific viral, parasitic, or bacterial infections (eg, hepatitis C, papillomavirus, schistosomes, Helicobacter), others to chronic nonspecific infections (eg, chronic urinary catheters with recurrent infections, chronic cholecystitis, draining cutaneous ulcers from osteomyelitis), and still others to noninfectious chronic inflammatory processes, such as ulcerative colitis, reflux esophagitis, chronic pancreatitis, and atrophic gastritis.2
With this large body of data in mind, the historical, mostly anecdotal, reports that lung cancers occasionally arose in pulmonary scars (so-called scar carcinomas) were consonant with these observations in other organs. Detailed statistical estimates of the incidence and risk of these cancers, however, awaited more recent studies of . . . [Full Text of this Article]
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Lung Cancer Risk Following Detection of Pulmonary Scarring by Chest Radiography in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Ying-Ying Yu, Paul F. Pinsky, Neil E. Caporaso, Nilanjan Chatterjee, Mona Baumgarten, Patricia Langenberg, Jon P. Furuno, Qing Lan, and Eric A. Engels
Arch Intern Med. 2008;168(21):2326-2332.
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