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Stretching the Supply or Wasting It?

Ann R. Falsey, MD

Arch Intern Med. 2008;168(22):2402-2403.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Seasonal influenza is responsible for 200 000 to 400 000 hospitalizations and 20 000 to 40 000 deaths annually in the United States.¹ At present, the cornerstone of influenza control is vaccination. Groups recommended by the Advising Committee on Immunization Practices (ACIP) to be vaccinated yearly include all adults older than 50 years, children aged 6 to 23 months, chronically ill persons, and health care workers. Although an effective live attenuated vaccine is approved for persons aged 5 to 49 years, trivalent inactivated vaccine (TIV) remains the primary method of vaccination for the majority of at-risk populations. The production of adequate supplies of yearly influenza vaccine is challenging for a number of reasons, including the need to anticipate new circulating strains in advance, adaptation of new variants for growth in embryonated hens' eggs, and an expanding target population. These issues are further complicated by the exodus of US vaccine manufacturers. . . . [Full Text of this Article]

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