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Comparative Effectiveness of β-Blockers in Elderly Patients With Heart Failure—Invited Commentary
Bertram Pitt, MD
Arch Intern Med. 2008;168(22):2431-2432.
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Treatment with BBs has been shown to reduce cardiovascular mortality and hospitalizations for HF in large-scale, placebo-controlled, randomized trials of patients with HF caused by left ventricular systolic dysfunction (LVSD).1-3 β-Blockers, along with angiotensin-converting enzyme (ACE) inhibitors4 and aldosterone-blocking agents,5 reduce mortality and hospitalization for HF in patients with HF caused by LVSD and have been given a class 1 indication in the American College of Cardiology/American Heart Association guidelines.6 However, despite the overwhelming evidence supporting the use of BBs in patients with HF caused by LVSD, many patients who seem to qualify for their use do not receive them.7 In part, this is the result of perceived tolerability, cost, a revulsion on the part of many patients and physicians to the use of polypharmacy, and the belief that randomized clinical trials in circumscribed patient populations do not reflect real-world conditions and do not apply to patients . . . [Full Text of this Article] AUTHOR INFORMATION
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RELATED LETTERS
Conflicts of Interest Need to Be Reported Reliably
Jeff Whittle
Arch Intern Med. 2009;169(11):1078-1079.
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Conflicts of Interest Need to Be Reported Reliably—Reply
Bertram Pitt
Arch Intern Med. 2009;169(11):1079.
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Comparative Effectiveness of β-Blockers in Elderly Patients With Heart Failure
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Comparative Effectiveness of β-Blockers in Elderly Patients With Heart Failure—Invited Commentary
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Conflicts of Interest Need to Be Reported Reliably--Reply
Pitt
Arch Intern Med 2009;169:1079-1079.
FULL TEXT
Conflicts of Interest Need to Be Reported Reliably
Whittle
Arch Intern Med 2009;169:1078-1079.
FULL TEXT
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