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Thomas Paparrigopoulos, MD; Elias Tzavellas, MD; Dimitris Karaiskos, MD; Ioannis Liappas, MD

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In their interesting study "Relations of Thyroid Function to Body Weight," Fox and colleagues maintain that baseline serum thyrotropin (TSH) concentrations are related to body weight.¹ The hypothesis that metabolism is regulated by thyroid hormones and energy expenditure is advanced as a potential mechanism, but no comment is made on the significance of caloric intake and food consumption. In this context, we would like to point out the association of mood and anxiety disorders with either overt or subclinical thyroid dysfunction as well as asymptomatic autoimmune thyroiditis, which are commonly linked to dietary changes.^2-3Concerning depression in particular, it should be noted that quite often TSH levels lie in the high end of the reference range, and an abnormal TSH response to TSH-releasing hormone is found in a considerable percentage of patients³; furthermore, triiodothyronine administration is included . . . [Full Text of this Article]

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Relations of Thyroid Function to Body Weight: Cross-sectional and Longitudinal Observations in a Community-Based Sample
Caroline S. Fox, Michael J. Pencina, Ralph B. D’Agostino, Joanne M. Murabito, Ellen W. Seely, Elizabeth N. Pearce, and Ramachandran S. Vasan
Arch Intern Med. 2008;168(6):587-592.
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