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COMMENTS AND OPINIONS
Particulate Air Pollution Exposure and Risk of Venous Thromboembolism
James E. Dalen, MD, MPH
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The report by Baccarelli et al1 would appear to be the first to indicate that exposure to particulate air pollution increases the risk of deep vein thrombosis. They report that depending on the level of exposure to particulate matter of less than 10 µm in aerodynamic diameter, the relative risk of deep vein thrombosis may be increased from 1.7 to more than 10.0 in patients living in the Lombardy region of Italy.
They note that the increased risk does not occur in women taking oral contraceptives or estrogen therapy, and that the risk is not increased in those with laboratory evidence of thrombophilia. This is in marked contrast to the other known risk factors for venous thromboembolism.
They suggest that the increased incidence of deep vein thrombosis is due to shortening of the prothrombin time secondary to the exposure to particulate matter. However, in their . . . [Full Text of this Article] AUTHOR INFORMATION
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Exposure to Particulate Air Pollution and Risk of Deep Vein Thrombosis
Andrea Baccarelli, Ida Martinelli, Antonella Zanobetti, Paolo Grillo, Li-Fang Hou, Pier A. Bertazzi, Pier Mannuccio Mannucci, and Joel Schwartz
Arch Intern Med. 2008;168(9):920-927.
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