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Reto Auer, MD; Nicolas Rodondi, MD, MAS

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In their article, Åsvold et al¹ report the findings of the Nord-Trøndelag Health Study (HUNT Study), in which they found a linear and positive association of thyrotropin (TSH) levels within the reference range (0.5-3.5 mIU/L) with coronary heart disease (CHD) mortality in women. In the context of previous studies that did not find an increased risk of CHD with higher TSH levels,^2-4 we would like to point out some limitations of the data presented and that these data should be interpreted with caution before clinical use or future revision of guidelines.

Åsvold et al¹ report the hazard ratios for 3 analyzed groups of TSH levels (0.5-1.4, 1.5-2.4, and 2.5-3.5 mIU/L) among 5 (<0.5, 0.5-1.4, 1.5-2.4, 2.5-3.5, and 3.6 mIU/L) described in the "Statistical Analysis" section. They provide only raw data on CHD mortality for participants with a TSH level of 3.6 mIU/L or . . . [Full Text of this Article]

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RELATED ARTICLE

Thyrotropin Levels and Risk of Fatal Coronary Heart Disease: The HUNT Study
Bjørn O. Åsvold, Trine Bjøro, Tom Ivar L. Nilsen, David Gunnell, and Lars J. Vatten
Arch Intern Med. 2008;168(8):855-860.
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Thyrotropin Levels and Coronary Heart Disease Mortality—Reply
Bjørn O. Åsvold, Trine Bjøro, Tom Ivar L. Nilsen, David Gunnell, and Lars J. Vatten
Arch Intern Med. 2008;168(22):2499.
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