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COMMENTS AND OPINIONS
Thyrotropin Levels and Coronary Heart Disease Mortality—Reply
Bjørn O. Åsvold, MD, PhD;
Trine Bjøro, MD, PhD;
Tom Ivar L. Nilsen, PhD;
David Gunnell, MD, PhD;
Lars J. Vatten, MD, PhD
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In reply
In a recent mortality follow-up of a large population with TSH measurements at baseline,1 we showed a positive association of TSH levels with risk of fatal CHD. In the analyses, we either adjusted for or stratified by sex, age, and smoking status. Other cardiovascular risk factors, such as serum lipid levels and blood pressure, are also correlated with TSH levels, but there is evidence that these correlations may be due to effects of thyroid hormones and, therefore, should not be regarded as confounders in the analysis. The age- and smoking-adjusted relative risk of fatal CHD was 1.38 (95% confidence interval [CI], 0.88-2.17) for women with a TSH level of 3.6 mIU/L or greater compared with women with a TSH level in the lower part of . . . [Full Text of this Article]
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