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Neal J. Weinreb, MD; Hans C. Andersson, MD; Maryam Banikazemi, MD; John Barranger, MD, PhD; Ernest Beutler, MD; Joel Charrow, MD; Gregory A. Grabowski, MD; Carla E. M. Hollak, MD, PhD; Paige Kaplan, MB, BCh; Henry Mankin, MD; Pramod K. Mistry, MD, PhD; Barry E. Rosenbloom, MD; Stephan vom Dahl, MD; Ari Zimran, MD

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The study by Landgren et al¹ investigated the risk of malignancy in patients with type 1 Gaucher disease (GD). We have several questions about their article that address the validity of the findings. First, we are concerned by the large number of patients with reported type 1 GD. The prevalence of type 1 GD is 1:40 000 to 60 000 in the general population and 1:500 to 800 among Ashkenazi Jews.^2-6 Recognizing that Ashkenazi Jews constitute no more than 2% to 3% of the US population, fewer than 200 patients with GD should be expected among 4.5 million . . . [Full Text of this Article]

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