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COMMENTS & OPINIONS
Prevalence of Type 1 Gaucher Disease in the United States
Neal J. Weinreb, MD;
Hans C. Andersson, MD;
Maryam Banikazemi, MD;
John Barranger, MD, PhD;
Ernest Beutler, MD;
Joel Charrow, MD;
Gregory A. Grabowski, MD;
Carla E. M. Hollak, MD, PhD;
Paige Kaplan, MB, BCh;
Henry Mankin, MD;
Pramod K. Mistry, MD, PhD;
Barry E. Rosenbloom, MD;
Stephan vom Dahl, MD;
Ari Zimran, MD
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The study by Landgren et al1 investigated the risk of malignancy in patients with type 1 Gaucher disease (GD). We have several questions about their article that address the validity of the findings. First, we are concerned by the large number of patients with reported type 1 GD. The prevalence of type 1 GD is 1:40 000 to 60 000 in the general population and 1:500 to 800 among Ashkenazi Jews.2-6 Recognizing that Ashkenazi Jews constitute no more than 2% to 3% of the US population, fewer than 200 patients with GD should be expected among 4.5 million . . . [Full Text of this Article]
AUTHOR INFORMATION
RELATED LETTER
Prevalence of Type 1 Gaucher Disease in the United States—Reply
Ola Landgren, Gloria Gridley, Neil E. Caporaso, and Ingemar Turesson
Arch Intern Med. 2008;168(3):327-328.
EXTRACT
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Risk of Malignant Disease Among 1525 Adult Male US Veterans With Gaucher Disease
Ola Landgren, Ingemar Turesson, Gloria Gridley, and Neil E. Caporaso
Arch Intern Med. 2007;167(11):1189-1194.
ABSTRACT
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Prevalence of Lysosomal Storage Disorders
Peter J. Meikle, John J. Hopwood, Alan E. Clague, and William F. Carey
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