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COMMENTS & OPINIONS
The Relationship Between Testosterone and Mortality in Men: A Debatable Issue
Thomas Paparrigopoulos, MD;
Elias Tzavellas, MD;
Dimitris Karaiskos, MD;
Ioannis Liappas, MD
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In their recently published study, Araujo et al1 come to the conclusion that in men, endogenous sex steroid levels appear to have relatively weak albeit significant associations with mortality. Nevertheless, even this weak connection should be regarded with caution because several confounding factors, which may further limit the significance of the finding, were not included in their analysis.
First, only sex steroid measurements were given, although it is more appropriate to measure testosterone and interpret findings in conjunction with measurements of plasma-luteinizing hormone.2 Moreover, although the circadian variation of testosterone is markedly dampened with advancing age,2 no adjustment was made for previous nighttime sleep quantity, which seems to be associated with a substantial part of the variability in the morning testosterone levels of older men.3 Second, the presence or absence of depressive symptoms, as a covariate, apparently was . . . [Full Text of this Article]
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RELATED LETTER
The Relationship Between Testosterone and Mortality in Men: A Debatable Issue—Reply
Andre B. Araujo, Varant Kupelian, Stephanie T. Page, David J. Handelsman, William J. Bremner, and John B. McKinlay
Arch Intern Med. 2008;168(3):330.
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RELATED ARTICLE
Sex Steroids and All-Cause and Cause-Specific Mortality in Men
Andre B. Araujo, Varant Kupelian, Stephanie T. Page, David J. Handelsman, William J. Bremner, and John B. McKinlay
Arch Intern Med. 2007;167(12):1252-1260.
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