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Robert J. Clarke, FRCP; Jonathan R. Emberson, PhD

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When assessing causal relations with blood lipids in epidemiological studies, the analysis of an aggregate of all causes will always be less informative than any cause-specific analysis. A meta-analysis of randomized trials of cholesterol-lowering statin therapy in patients 75 years or older demonstrated substantial reductions in the incidence of heart disease and stroke with no adverse effects on nonvascular causes of death.¹ While treatment decisions should be guided principally by the evidence from randomized trials, we have demonstrated that differences in low-density lipoprotein cholesterol levels that are achievable by statin therapy may be associated with a one-third lower risk of heart disease at all ages.² These results suggest that older people with or without established disease are likely to benefit from strategies to lower low-density lipoprotein cholesterol levels, including statin therapy.

AUTHOR INFORMATION
Correspondence: Dr Clarke, Clinical Trial Service Unit, University of . . . [Full Text of this Article]

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