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Pierre Fontana, MD, PhD; Jean-Luc Reny, MD, PhD

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In their meta-analysis, Snoep et al¹ found that "laboratory-defined aspirin resistance" was associated with an increased risk of recurrent cardiovascular events in aspirin-treated patients. However, this conclusion is undermined by a significant heterogeneity test result, even when using a random effects model. The authors included studies with very different designs and particularly different definitions of "aspirin resistance." Indeed, the biological tests used in the selected studies were either specific for aspirin inhibition of thromboxane (Tx)A₂ synthesis (measurement of TxB₂ levels or of arachidonic acid–induced platelet aggregation) or nonspecific (eg, template bleeding time or the Platelet Function Analyzer100 [Dade Behring, Deerfield, Illinois]).

Specific and nonspecific tests are drastically different, since the latter are not directly related to the effect of aspirin.² Indeed, TxA₂ is similarly inhibited by aspirin in subjects who are considered "aspirin resistant" and "aspirin responders" on the basis of nonspecific . . . [Full Text of this Article]

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