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James E. Dalen, MD, MPH

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The systematic review and meta-analysis of aspirin resistance by Snoep et al¹ found that patients with laboratory resistance to aspirin also have clinical resistance to aspirin as evidenced by higher risks of recurrent cardiovascular events. A very likely explanation of this association is that laboratory resistance and clinical resistance have the same cause—noncompliance.²

Schwartz et al³ reported that 17 of 190 patients taking aspirin daily were determined to be aspirin resistant by light transmission aggregometry. When questioned, 10 of the 17 admitted that they were not taking the aspirin. When retested after they were observed to take 325 mg of aspirin, none of the 17 were aspirin resistant. Tantry et al⁴ reported that 7 of 203 patients with coronary heart disease had laboratory aspirin resistance. When retested after being observed ingesting aspirin, none were resistant.

Failure to take aspirin will cause laboratory resistance to aspirin . . . [Full Text of this Article]

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RELATED ARTICLE

Association of Laboratory-Defined Aspirin Resistance With a Higher Risk of Recurrent Cardiovascular Events: A Systematic Review and Meta-analysis
Jaapjan D. Snoep, Marcel M. C. Hovens, Jeroen C. J. Eikenboom, Johanna G. van der Bom, and Menno V. Huisman
Arch Intern Med. 2007;167(15):1593-1599.
ABSTRACT | FULL TEXT  

RELATED LETTER

Is Aspirin Resistance Due to Noncompliance?—Reply
Jaapjan D. Snoep, Marcel M. C. Hovens, Jeroen C. J. Eikenboom, Johanna G. van der Bom, and Menno V. Huisman
Arch Intern Med. 2008;168(5):550.
EXTRACT | FULL TEXT