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Niki Katsiki, MD; Christos Manes, MD, PhD

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The Women's Antioxidant Cardiovascular Study (WACS) was conducted to evaluate the effects of antioxidant vitamins on the risk of cardiovascular events.¹ Regarding the limitations of this study, apart from the lack of complete follow-up and compliance reported by the authors, some other points should have been discussed. First, only women were included in the trial. No information about premenopausal or postmenopausal status of the study population was given. Moreover, dietary habits of the participants were not taken into account, despite the fact that antioxidant clinical studies should investigate the impact of a rich-in-antioxidant-nutrients diet in conjunction with the administration of vitamin supplements, as mentioned in the introduction.

Furthermore, the dose of vitamin E (600 IU every other day) may be responsible for the observed neutral results, since it is lower than the one (400 or 600 IU/d) used in the majority of the . . . [Full Text of this Article]

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