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Nancy R. Cook, ScD; Christine M. Albert, MD, MPH; JoAnn E. Manson, MD, DrPH; for the WACS Investigator Group

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In reply

We thank Katsiki and Manes for their interest in our study,¹ which addresses the role of antioxidant vitamins, alone and in combination, in the prevention of cardiovascular events. Although our trial included only women, several antioxidant trials have been conducted in men or women separately, with similar results.²

We note that we provided information about the menopausal status of the study population in our article; this information is presented in Table 1, with subgroup effects by menopausal status given in Table 3.¹

Participants in WACS represent a relatively well-nourished population of female health professionals. Women in the trial were asked to avoid taking supplements above the recommended daily allowance for these agents. The prevalence of multivitamin use at baseline is presented in Table 1¹ and was similar across randomized . . . [Full Text of this Article]

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