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COMMENTS AND OPINIONS
Spontaneous Regression of Breast Cancer
Catherine Richards, MPH
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The recent article published by Zahl et al1 brought up some very interesting discrepancies in incidence rates of invasive breast cancer between screened and unscreened groups of women in the Norwegian Breast Cancer Screening Program. At the end of the study, there was a much lower rate of invasive breast cancer diagnosed in the unscreened group, which the authors contribute to spontaneous regression. According to their theory, if all invasive tumors that develop are persistent, then at the end of the study period, the screened group and the control group should have a similar incidence, and since this is not observed, then some tumors must spontaneously regress.
The authors test a lot of alternative theories to their conclusions and seem to prove that their theory still holds. However, there is a potentially fatal mistake that the authors make when refuting the alternative hypothesis that hormone therapy (HT) . . . [Full Text of this Article] AUTHOR INFORMATION
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The Natural History of Invasive Breast Cancers Detected by Screening Mammography
Per-Henrik Zahl, Jan Mæhlen, and H. Gilbert Welch
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