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COMMENTS AND OPINIONS
Spontaneous Regression of Invasive Breast Cancer: Does This Study Answer the Question?
Mette Kalager, MD;
Michael Bretthauer, MD, PhD
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The article by Zahl et al1 points to an important topic in screening mammography: spontaneous regression of invasive breast cancer. The article lacks any explanation of the reasons for the expected difference in cumulative incidence between the screened group and the control group (see Figure 2 in the article by Zahl et al1).
The 2 comparison groups have two-thirds of the same women in common. Consequentially, for the women in common in both groups, breast cancer incidence in the first round of the screened group and the prevalence screen of the control group must be identical because they reflect the very same mammographic screening examinations. In turn, only one-third of the women in the study cohorts are different and thus are able to contribute to the difference in incidence between the groups; ie, only women aged 50 to 54 years in the . . . [Full Text of this Article] AUTHOR INFORMATION
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The Natural History of Invasive Breast Cancers Detected by Screening Mammography
Per-Henrik Zahl, Jan Mæhlen, and H. Gilbert Welch
Arch Intern Med. 2008;168(21):2311-2316.
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