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William B. Grant, PhD

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The recent article¹ reporting an ethnic difference in incidence of congestive heart failure (CHF) is an important finding. However, the authors had difficulty in identifying the reasons for the differences, but they did suggest that reducing the risk of diabetes and hypertension would reduce the risk of CHF.

I suggest that differences in serum 25-hydroxyvitamin D (25[OH]D) or 1,25-dihydroxyvitamin D (1,25[OH]2D) levels might explain much of the differences. Two recent articles reported observational results for CHF with respect to vitamin D. One study found that after adjustment for potential confounders, those in the lowest serum calcitriol (1.25[OH]2D) level tertile (<16.5 pg/mL [to convert to picomoles per liter, multiply by 2.6]) had a higher mortality rate than patients in the highest calcitriol level tertile (>28.1 pg/mL), with a hazard ratio for an event of 0.51 (95% confidence interval [CI], 0.33-0.77).² In the other study, after adjustment for . . . [Full Text of this Article]

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