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Armin Zittermann, PhD; William B. Grant, PhD

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Melamed and colleagues¹ are to be congratulated for their important findings on mortality risk according to 25-hydroxyvitamin (25[OH]D) levels in the general population. In their unadjusted data, there was a consistent decrease in all-cause mortality risk across 25 (OH)D quartiles, with a higher mortality risk at lower 25 (OH)D concentrations. However, their fully adjusted model suggests that mortality risk is lowest when 25(OH)D concentrations are approximately 35 ng/mL and that there is again a higher risk of mortality at levels higher than 50 ng/mL, at least in women. The fully adjusted model included various variables such as age, physical activity, body mass index, race, and smoking status. Others^2-3 have performed similar exploratory data analyses, and their results also suggest that 25(OH)D levels that are now recommend by some vitamin D researchers⁴ (>30 ng/mL) may already be harmful. Some of the aforementioned data are . . . [Full Text of this Article]

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25-Hydroxyvitamin D Levels and the Risk of Mortality in the General Population
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25-Hydroxyvitamin D Levels and All-Cause Mortality—Reply
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Arch Intern Med. 2009;169(11):1076.
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