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Jordi Salas-Salvadó, MD, PhD; Emilio Ros, MD, PhD; Ramon Estruch, MD, PhD; Maríia-Isabel Covas, DPharm, PhD; for the PREDIMED Study Investigators

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We thank Esposito and Giugliano for their comments on our study of the effects of 2 enhanced Mediterranean diets vs a low-fat diet on MetS status.¹ As reported, 3 clinical studies assessing the effects of dietary patterns on MetS had been previously published,^2-4 and Esposito and Giugliano rightly point out that the test diets in these studies, which were similar in many aspects to the Mediterranean diet, were associated with better responses in terms of resolution of the MetS. Thus, these authors contend that our Spanish participants appear to be more resistant to the effects of the diet than those from Italy,² the United States,³ or Iran.⁴ However, they fail to recognize an important differential feature from our study, namely that the interventional diets were ad libitum, . . . [Full Text of this Article]

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Effect of a Mediterranean Diet Supplemented With Nuts on Metabolic Syndrome Status: One-Year Results of the PREDIMED Randomized Trial
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