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Simon N. Thornton, PhD

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

It was with great interest that I read the recent article by Alpérovitch and colleagues¹ titled "Relationship Between Blood Pressure and Outdoor Temperature in a Large Sample of Elderly Individuals: The Three-City Study." As much as I agree that the subject itself is interesting, there is a very important aspect left out of this article, and that is tissue perfusion. One of the principal problems of tissue perfusion is having enough blood volume to do this. If there is insufficient volume, then constant redistribution will have to take place, and an insufficient tissue perfusion is associated with hypertension.²

Two indicators of insufficient blood volume are plasma levels of the peptide hormones antidiuretic hormone (ADH) and angiotensin (AngII). In the cold, however, the secretion of ADH is attenuated, and this could lead to an exaggerated decrease in blood volume unless there was a compensatory increase in fluid . . . [Full Text of this Article]

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RELATED ARTICLE

Relationship Between Blood Pressure and Outdoor Temperature in a Large Sample of Elderly Individuals: The Three-City Study
Annick Alpérovitch, Jean-Marc Lacombe, Olivier Hanon, Jean-François Dartigues, Karen Ritchie, Pierre Ducimetière, and Christophe Tzourio
Arch Intern Med. 2009;169(1):75-80.
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