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Wendy P. J. den Elzen, MSc; Rudi G. J. Westendorp, MD, PhD; Marijke Frölich, PhD; Wouter de Ruijter, MD; Willem J. J. Assendelft, MD, PhD; Jacobijn Gussekloo, MD, PhD

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In reply

We thank Andrès and Federici for their interest in our study and appreciate their response to the issues we raised. They argue that vitamin B₁₂ deficiency is of importance in old age, as clinical examinations of elderly patients with anemia often reveal combinations of iron, folate, and vitamin B₁₂ deficiency that are easily treated by oral or parenteral supplementation.

In contrast, we presented data that low vitamin B₁₂ levels in 85-year-old subjects in the general population is not associated with anemia. The prevalence of anemia was similar in subjects with vitamin B₁₂ deficiency (<150 pmol/L [to convert to picograms per milliliter, divide by 0.7378]) and subjects with normal vitamin B₁₂ levels. In addition, subjects with low vitamin B₁₂ levels . . . [Full Text of this Article]

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RELATED ARTICLE

Vitamin B₁₂ and Folate and the Risk of Anemia in Old Age: The Leiden 85-Plus Study
Wendy P. J. den Elzen, Rudi G. J. Westendorp, Marijke Frölich, Wouter de Ruijter, Willem J. J. Assendelft, and Jacobijn Gussekloo
Arch Intern Med. 2008;168(20):2238-2244.
ABSTRACT | FULL TEXT  

RELATED LETTER

Role of Vitamin B₁₂ in Anemia in Old Age
Emmanuel Andrès and Laure Federici
Arch Intern Med. 2009;169(12):1167-1168.
EXTRACT | FULL TEXT