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Marie A. de Perio, MD; Joel Tsevat, MD, MPH; Gary A. Roselle, MD; Stephen M. Kralovic, MD, MPH; Mark H. Eckman, MD, MS

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In reply

We appreciate the opportunity to respond to the thoughtful comments of Mancuso and colleagues concerning new data on the test characteristics of interferon gamma release assays (IGRAs) published after our cost-effectiveness analysis article¹ was accepted for publication. Mancuso and colleagues express concern that the latest meta-analysis by Pai and colleagues² reported a pooled sensitivity of 77% for the TST vs our pooled value of 67%; 78% for the QuantiFERON-TB Gold (QFT-G) (Cellestis Limited) vs our value of 83%; and 70% for the QFT-GIT vs our value of 76%.^1-2

Our decision model stratified health care workers undergoing IGRA testing into those with vs without indeterminate results.¹ Therefore, the proportion of true-positive and true-negative results among those with definitive results is somewhat different from overall sensitivity and . . . [Full Text of this Article]

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