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Adit A. Ginde, MD, MPH; Jonathan M. Mansbach, MD; Carlos A. Camargo Jr, MD, DrPH

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In reply

We thank Dr Hemilä for this correspondence. The Cochrane review by Douglas et al¹ supported our statement that vitamin C has a limited role in prevention and treatment of colds and concluded that the prophylactic or therapeutic use of vitamin C does not reduce the incidence or severity of colds. There was a modest reduction (approximately 12 hours) in duration of colds with prophylactic but not therapeutic use of vitamin C, but as those authors conclude, "there seems no justification for routine mega-dose vitamin C supplementation in the normal population" and "therapeutic supplementation has not been shown to be beneficial."¹

We agree that observational data have limitations, particularly in nutrition research. As demonstrated by the vitamin E experience,² randomized controlled trials may provide different conclusions than suggested by preceding observational studies, often because . . . [Full Text of this Article]

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