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Cédric Annweiler, MD, MS; Olivier Beauchet, MD, PhD

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Recently, Bischoff-Ferrari et al¹ reported the results of an interesting meta-analysis on the efficacy of oral supplemental vitamin D in preventing nonvertebral fractures in older adults. The findings showed a dose-dependant protective effect of vitamin D against fractures, which was independent of additional calcium supplementation. A significant effect of supplementation was observed for a dose above 400 IU/d and reduced the nonvertebral fracture rate by 20%.¹

It is now well recognized that low-energy nonvertebral fractures in elderly persons depend on the combination of a fall and a bone weakened by osteoporosis.² As well, it is admitted that vitamin D supplementation reduces the bone fracture rate through both nonbone and bone actions.^1-4 Five years ago, Bischoff-Ferrari et al³ highlighted in a meta-analysis a significant effect of vitamin D supplementation in terms of fall rate reduction in elderly individuals. A neuromuscular effect resulting in . . . [Full Text of this Article]

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RELATED ARTICLE

Prevention of Nonvertebral Fractures With Oral Vitamin D and Dose Dependency: A Meta-analysis of Randomized Controlled Trials
Heike A. Bischoff-Ferrari, Walter C. Willett, John B. Wong, Andreas E. Stuck, Hannes B. Staehelin, E. John Orav, Anna Thoma, Douglas P. Kiel, and Jana Henschkowski
Arch Intern Med. 2009;169(6):551-561.
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Relationship Between Bone, Fracture, and Exercise: The Key Role of Vitamin D—Reply
Heike A. Bischoff-Ferrari, Walter C. Willett, John B. Wong, Andreas E. Stuck, Hannes B. Staehelin, E. John Orav, Anna Thoma, Douglas P. Kiel, and Jana Henschkowski
Arch Intern Med. 2009;169(17):1638.
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