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Heike A. Bischoff-Ferrari, MD, DrPH; Walter C. Willett, DrPH; John B. Wong, MD; Andreas E. Stuck, MD; Hannes B. Staehelin, MD; E. John Orav, PhD; Anna Thoma, MD; Douglas P. Kiel, MD; Jana Henschkowski, MD

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Annweiler and Beauchet suggest that the 20% nonvertebral fracture reduction with vitamin D supplementation at a dose greater than 400 IU/d may in part be explained by a direct benefit of vitamin D on muscle, resulting in fewer falls and thereby fewer fractures. The comment by Annweiler and Beauchet is supported by the presence of the vitamin D receptor in human muscle tissue¹ and a rapid^2-3 and sustained^4-7 effect of vitamin D supplementation on falls from several trials. Thus, we agree—although falls were not assessed in our meta-analysis,⁸ supplementation likely resulted in reduced falls contributing to the observed fracture risk reduction.

AUTHOR INFORMATION
Correspondence: Dr Bischoff-Ferrari, Department of Rheumatology and Institute of Physical Medicine, University . . . [Full Text of this Article]

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RELATED LETTERS

Prevention of Nonvertebral Fractures With Oral Vitamin D and Dose Dependency: A Meta-analysis of Randomized Controlled Trials
Heike A. Bischoff-Ferrari, Walter C. Willett, John B. Wong, Andreas E. Stuck, Hannes B. Staehelin, E. John Orav, Anna Thoma, Douglas P. Kiel, and Jana Henschkowski
Arch Intern Med. 2009;169(6):551-561.
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Relationship Between Bone, Fracture, and Exercise: The Key Role of Vitamin D
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RELATED ARTICLE

Prevention of Nonvertebral Fractures With Oral Vitamin D and Dose Dependency: A Meta-analysis of Randomized Controlled Trials
Heike A. Bischoff-Ferrari, Walter C. Willett, John B. Wong, Andreas E. Stuck, Hannes B. Staehelin, E. John Orav, Anna Thoma, Douglas P. Kiel, and Jana Henschkowski
Arch Intern Med. 2009;169(6):551-561.
ABSTRACT | FULL TEXT