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Comment on "Antidepressant Use and Risk of Incident Cardiovascular Morbidity and Mortality Among Postmenopausal Women in the Women's Health Initiative Study"

Christopher O’Connor, MD; Mona Fiuzat, PharmD

Arch Intern Med. 2009;169(22):2140-2141.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Depression is a common comorbidity in patients with chronic heart failure, with reported incidence as high as approximately 48% in this patient population.^1-4 Studies have shown that depression in patients with heart failure is strongly associated with worse outcomes and is an independent predictor of increased mortality and hospitalization.^5-9 As a result, the use of antidepressants in this population has become more prevalent.

Some studies have shown improvements in cardiovascular outcomes and functional status with the use of selective serotonin reuptake inhibitors (SSRIs) with no adverse safety signals observed.^{6, 10-11} However, other studies of tricyclic antidepressants (TCAs) and SSRIs have raised questions regarding the safety of these antidepressants for use in patients with cardiac disease because treatment with these agents was associated with increased risk of myocardial infarction or cardiovascular death.^12-13 Most notably, in the Cardiac Arrhythmia Suppression Trial,¹⁴ TCAs were found to be associated . . . [Full Text of this Article]

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RELATED ARTICLE

Antidepressant Use and Risk of Incident Cardiovascular Morbidity and Mortality Among Postmenopausal Women in the Women's Health Initiative Study
Jordan W. Smoller, Matthew Allison, Barbara B. Cochrane, J. David Curb, Roy H. Perlis, Jennifer G. Robinson, Milagros C. Rosal, Nanette K. Wenger, and Sylvia Wassertheil-Smoller
Arch Intern Med. 2009;169(22):2128-2139.
ABSTRACT | FULL TEXT  

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Antidepressant Use and Cardiovascular Risk in Postmenopausal Women
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