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COMMENTS AND OPINIONS
A Ray of Sunshine for the Vitamin D–Heart Hypothesis
Beatrice Golomb, MD, PhD;
Eli Aronoff-Spencer, MD, PhD;
Michael Steadman, MD;
Winnie Wu, MS;
Arthur Yan, MD
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We suggest that the observation by Giovannucci et al,1 linking higher plasma 25-hydroxyvitamin D concentrations to lower myocardial infarction risk in men, bears fewer discrepancies with existing literature than the authors presume. The authors note that their observational findings disagree with the findings from the largest randomized trial of vitamin D, the Women's Health Initiative (WHI) study, in which the vitamin D + calcium group exhibited no benefit—nor trend to benefit—against myocardial infarction (hazard ratio, 1.04; 95% confidence interval, 0.92-1.18).2
We propose that this difference may arise, not primarily from the relatively low vitamin D dose of 400 IU/d, as the authors suggest, but from the inclusion of calcium with vitamin D supplementation in the WHI: a recent double-blind randomized controlled trial in postmenopausal women reported an apparent increase in myocardial infarction incidence in those . . . [Full Text of this Article]
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