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Serge Hercberg, MD, PhD; Sebastien Czernichow, MD, PhD; Pilar Galan, MD, PhD

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We read with interest the recent article by Harding et al¹ who concluded that higher plasma vitamin C concentration and, to a lesser degree, fruit and vegetable intake were associated with a substantially decreased risk of diabetes. The problem raised in the discussion by the authors is to ascertain if the strong independent association they observed in their prospective study is linked to a beneficial effect of vitamin C and/or fruit and vegetable intake. As suggested by the authors, the only way to confirm if vitamin C intake by itself may reduce the risk of diabetes is to develop designed clinical trials using vitamin C supplementation in populations without diabetes at inclusion.

We performed, in France, the Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) study, a randomized double-blind, placebo-controlled, primary prevention trial initially designed to test, on a . . . [Full Text of this Article]

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